Neurology articles from across Nature Portfolio

Training a model on fetal and paediatric magnetic resonance images with synthesized artefacts enhances the model’s generalization across downstream tasks and patient populations.

Dementia is a major public health burden, and determining its lifetime risk is essential to inform prevention strategies. In a large cohort study of adults, 42% of participants ≥55 years of age developed dementia by age 95. Lifetime dementia risk was highest among women and Black adults, highlighting the importance of addressing underlying inequalities.

The co-effects of hypoxic postconditioning on SCF^KDM2A complex and USP22 significantly hindered nuclear β-catenin degradation through the ubiquitin proteasome pathway, leading to nuclear β-catenin stabilization and cerebral ischemic tolerance.

Two new phosphorylation sites, p-tau₂₆₂ and p-tau₃₅₆, detect the formation of prefibrillar tau aggregates and may serve as early-stage biofluid-based biomarkers of tau neurofibrillary tangle pathology in Alzheimer’s disease.

Implementation of patient and public involvement and engagement (PPIE) to enable patients and carers to feel included and equal to healthcare professionals is challenging to do well. Here, leaders of a PPIE group share their lived experience and highlight the importance of addressing the needs of all participants to enable true partnership.

Patient and public involvement and engagement is increasingly mandated in funding applications, yet often remain tokenistic and transitory. Working with patient and public contributors requires investment, thought, care and time. We discuss approaches that aim to increase agency for coresearchers, with the goal of strengthening public confidence and trust in research.

Rusty Gage describes how evidence for neurogenesis in the adult human hippocampus shaped our understanding of learning, memory and mental health.

Training a model on fetal and paediatric magnetic resonance images with synthesized artefacts enhances the model’s generalization across downstream tasks and patient populations.