Nanographenes, finite models of graphene sheets, are endowed with intriguing optical, electronic, and spintronic features which can be tuned by replacing carbon via heteroatom-doping. Here the authors extend the concept of heteroatom nanographene doping to include metal centers.

Ferroelectrics, which exhibit excellent charge separation ability, suffer from poor photocatalytic activity. The authors unveil the limitations in charge extraction and offer strategies to design high-performance photocatalysts by eliminating surface defects.

Here authors investigate the effects of different metals incorporated in the structures and possible additional phases have on the CO₂ uptake of pyrene-based MOFs. Results show that when additional phases are present, the pore volume is reduced and CO₂ binding sites in the structure are different, leading to different adsorption properties.

There is a long-standing trade-off between high piezoelectricity and good temperature stability for piezoceramics. Here, authors combine phase boundary engineering and process engineering to relieve this relationship in (Pb, Zr) TiO3 piezoceramics.

Lung cancer screening (LCS) requires effectively and efficiently mining big, multimodal datasets. Here, the authors develop a medical multimodal-multitask foundation model (M3FM) for LCS from 3D low-dose computed tomography and medical multimodal data, outperforming state-of-the-art methods and allowing the identification of informative data elements.

Import restrictions on deforestation-linked commodities, like oil crops, could cut land-use emissions but risk emissions leakage globally and economic losses for producers. Direct forest protection may be more effective than import restrictions.

Here authors investigate the effects of different metals incorporated in the structures and possible additional phases have on the CO₂ uptake of pyrene-based MOFs. Results show that when additional phases are present, the pore volume is reduced and CO₂ binding sites in the structure are different, leading to different adsorption properties.

Across many North American forests, recent years with exceptional area burned are not unprecedented when considering the multi-century perspective offered by fire-scarred trees. Nevertheless, abundant evidence suggests that the severity of contemporary wildfire is unprecedented in its adverse impacts on forests and humans.

Projections of future sea level rely on the understanding of the relationship between sea-level and past climate changes. This study reconstructs 30,000 years of sea level evolution along Atlantic Africa in response to the climatic modifications.

Several Pacific deep-ocean ferromanganese crusts record an anomalous increase of the cosmogenic radionuclide ¹⁰Be around 10.1 Ma. This anomaly is a potential independent time marker for the late Miocene.

Functional tissue units (FTUs) form the basic building blocks of organs and are important for understanding and modeling their healthy physiological function and disease states. Here, the authors present a catalog of 22 anatomically based FTUs from 10 healthy human organs as part of an ongoing international effort to construct a Human Reference Atlas of all cells in the human body.

Translocation into neurons is crucial for BoNT/A1 action. Here, the authors show by single-particle cryo-EM that BoNT/A1 bound to its receptor SV2B switches its conformation from an open, translocation-incompatible to a semi-closed, translocation-competent state at acidic pH.

Fu et al. describe a pathogen effector, HaRxL10 that suppresses plant immunity and interferes with plant development by hijacking the clock component CHE to perturb its function in transcriptional regulation.

Lung cancer screening (LCS) requires effectively and efficiently mining big, multimodal datasets. Here, the authors develop a medical multimodal-multitask foundation model (M3FM) for LCS from 3D low-dose computed tomography and medical multimodal data, outperforming state-of-the-art methods and allowing the identification of informative data elements.

This study maps proteomic changes in Alzheimer’s mouse models, identifying shared pathways with humans, amyloid-driven protein turnover, and proteome-transcriptome differences, offering insights into disease mechanisms and potential targets.

Disturbed lipid metabolism is a feature of diabetic kidney disease (DKD). Here the authors report that ceramide synthase 6 (CerS6) in podocytes contributes to the pathogenesis of diabetic kidney disease (DKD) in male mice by inducing mitochondrial DNA leakage, activating the cGAS-STING pathway and promoting inflammation.

A multi-ancestry genome-wide association study meta-analysis of chronic back pain in 553,601 participants from the Million Veteran Program revealed 67 new genome-wide significant loci with gene enrichment in brain and pituitary tissues.

Alveolar bone resorption (ABR) is a key pathological manifestation in the development of apical periodontitis (AP) that contributes to the AP-associated tooth loss, and whose underlying mechanism is largely unknown. Here, the authors show a molecular mechanism on osteoclastogenesis-related ABR and provides a therapeutic target of AP via modulating the FTO/HK1/USP14/RANK axis.

Import restrictions on deforestation-linked commodities, like oil crops, could cut land-use emissions but risk emissions leakage globally and economic losses for producers. Direct forest protection may be more effective than import restrictions.

Rossetti and coauthors explore how human cooperation dynamics shift when players engage in multiple economic games at the same time, rather than treating each game as isolated. The authors find that cognitive constraints, strategic motives, and spillover effects can reduce cooperation in such scenarios, challenging traditional models of direct reciprocity.

Companies benefit from some discretion on how to disclose their emissions, leading to potential underestimations of GHG footprints. Focusing on direct methane emissions, this paper quantifies a sizeable emission gap and associated transition risks.

This study explores single-cell protein (SCP) production via renewable electricity, outlining cost trajectories and scalability. SCP could become a sustainable and affordable protein supply, decoupling food systems from land and water constraints.

Here the authors show that an emotion regulation intervention for reducing negative intergroup emotions in conflicts can decrease negative emotions not only in treated participants but also in nontreated participants through emotion regulation contagion.