Biomarkers articles from across Nature Portfolio

New evidence suggests that Ruminococcus gnavus in the gut induces monoamine synthesis and neurotoxicity in some patients with cirrhosis, causing hepatic encephalopathy — revealing a possible therapeutic target or predictive biomarker for this understudied condition.

In January 2024, a Hevolution Alliance for Aging Biomarkers thinktank convened at Cold Spring Harbor to discuss the framework for creating an open and diverse data resource for developing reliable aging biomarkers. As the funding for this initiative has now been confirmed, we summarize recommendations and key milestones for its implementation.

A study in Nature Medicine developed a new clinical test based on a gut metagenome-derived multispecies biomarker panel for the diagnosis of inflammatory bowel disease, which outperformed faecal calprotectin. Shortly after, a study in Cell identified a health-relevant network-based core microbiome that could substantially advance precision microbiome medicine.

A scientist’s personal journey through breast cancer underscores the urgency for greater empathy in research and healthcare, a patient-centred approach to data dissemination, and more comprehensive, streamlined support for early-career researchers navigating health crises.

New evidence suggests that Ruminococcus gnavus in the gut induces monoamine synthesis and neurotoxicity in some patients with cirrhosis, causing hepatic encephalopathy — revealing a possible therapeutic target or predictive biomarker for this understudied condition.

In January 2024, a Hevolution Alliance for Aging Biomarkers thinktank convened at Cold Spring Harbor to discuss the framework for creating an open and diverse data resource for developing reliable aging biomarkers. As the funding for this initiative has now been confirmed, we summarize recommendations and key milestones for its implementation.

A study in Nature Medicine developed a new clinical test based on a gut metagenome-derived multispecies biomarker panel for the diagnosis of inflammatory bowel disease, which outperformed faecal calprotectin. Shortly after, a study in Cell identified a health-relevant network-based core microbiome that could substantially advance precision microbiome medicine.

Wearable sweat biosensors enable the non-invasive, real-time monitoring of hormones. Here, we highlight the development and commercialization of a wearable technology that can measure hormone levels in sweat for women’s health applications, including fertility tracking and menopause management.

SCORPIO is a machine learning system that predicts the efficacy of therapy with immune checkpoint inhibitors in patients with cancer, using only routine blood tests and basic clinical data. Predictions using SCORPIO were more accurate than those using FDA-approved biomarkers such as tumor mutational burden and PD-L1 expression, suggesting that SCORPIO offers a reliable, noninvasive and widely accessible tool to advance precision oncology for patients globally.