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Recommendations for implementing the Hevolution Alliance for Aging Biomarkers initiative

Nature Aging (2025)Cite this article

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In January 2024, a Hevolution Alliance for Aging Biomarkers thinktank convened at Cold Spring Harbor to discuss the framework for creating an open and diverse data resource for developing reliable aging biomarkers. As the funding for this initiative has now been confirmed, we summarize recommendations and key milestones for its implementation.

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Fig. 1: Recommended target aging measures and biomarkers.
Fig. 2: Workflow for the creation of Hevolution database.

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Acknowledgements

This work was supported in part by National Institute on Aging intramural research program.

Author information

Author notes

  1. These authors contributed equally: Toshiko Tanaka, Felipe Sierra.

  2. These authors jointly supervised this work: Viviana Perez, Luigi Ferrucci.

Authors and Affiliations

  1. Intramural Research Program of the National Institute on Aging, NIH, Baltimore, MD, USA

    Toshiko Tanaka & Luigi Ferrucci

  2. Hevolution Foundation https://hevolution.com/

    Felipe Sierra, Viviana Perez, Jens Eckstein, William Greene & Sophia Pathai

  3. Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Vadim N. Gladyshev & Vadim N. Gladyshev

  4. Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA

    Tony Wyss-Coray

  5. Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA

    Ana Maria Cuervo

  6. Indiana University School of Public Health, Bloomington, IN, USA

    David B. Allison

  7. Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA

    John R. Beard & Linda P. Fried

  8. Department of Epidemiology, Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA

    Daniel W Belsky

  9. Department of Geriatrics and Aging Research, University Hospital Zürich, Zurich, Switzerland

    Heike A. Bischoff-Ferrari

  10. Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA

    Eileen M. Crimmins

  11. Altos Labs, San Diego, CA, USA

    Steve Horvath

  12. Department of Medical Gerontology, Trinity College Dublin, Dublin, Ireland

    Rose Anne Kenny

  13. Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Stephen B. Kritchevsky

  14. Cambridge Public Health, University of Cambridge, Cambridge, UK

    Louise Lafortune

  15. Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Andrea B. Maier

  16. Department of Psychology and Neuroscience, Duke University, Durham, NC, USA

    Terrie E. Moffitt

  17. McMaster University, Hamilton, Ontario, Canada

    Parminder Raina

  18. School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

    Joanne Ryan

  19. Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Jonathan C. Silverstein

  20. Department of Obstetrics and Gynecology, and Department of Genetics and Development, Columbia University, New York, NY, USA

    Yousin Suh

Authors
  1. Toshiko Tanaka
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  2. Felipe Sierra
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  3. Vadim N. Gladyshev
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  4. Tony Wyss-Coray
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  5. Ana Maria Cuervo
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  6. Viviana Perez
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  7. Luigi Ferrucci
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Consortia

On behalf of the Hevolution Alliance for Aging Biomarkers

  • David B. Allison
  • , John R. Beard
  • , Daniel W Belsky
  • , Heike A. Bischoff-Ferrari
  • , Eileen M. Crimmins
  • , Ana Maria Cuervo
  • , Jens Eckstein
  • , Luigi Ferrucci
  • , Linda P. Fried
  • , Vadim N. Gladyshev
  • , William Greene
  • , Steve Horvath
  • , Rose Anne Kenny
  • , Stephen B. Kritchevsky
  • , Louise Lafortune
  • , Andrea B. Maier
  • , Terrie E. Moffitt
  • , Sophia Pathai
  • , Viviana Perez
  • , Parminder Raina
  • , Joanne Ryan
  • , Felipe Sierra
  • , Jonathan C. Silverstein
  • , Yousin Suh
  • , Toshiko Tanaka
  •  & Tony Wyss-Coray

Contributions

L.F., T.T., F.S. and V.P. wrote the paper. All authors contributed to the critical review of the manuscript.

Corresponding authors

Correspondence to Viviana Perez or Luigi Ferrucci.

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Competing interests

The authors declare no competing interests.

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Tanaka, T., Sierra, F., Gladyshev, V.N. et al. Recommendations for implementing the Hevolution Alliance for Aging Biomarkers initiative. Nat Aging (2025). https://doi.org/10.1038/s43587-025-00812-6

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  • DOI: https://doi.org/10.1038/s43587-025-00812-6

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