SYSTEMATIC REVIEW   Free access

European Journal of Physical and Rehabilitation Medicine 2018 June;54(3):450-62

DOI: 10.23736/S1973-9087.17.04680-9

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Active exergames to improve cognitive functioning in neurological disabilities: a systematic review and meta-analysis

Gioia MURA ¹ ✉, Mauro G. CARTA ¹, Federica SANCASSIANI ¹, Sergio MACHADO ^{2, 3, 4}, Luca PROSPERINI ^{5, 6}

¹ Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; ² Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro (IPUB/UFRJ), Rio de Janeiro, Brazil; ³ National Institute of Translational Medicine (INCT-TM), Rio de Janeiro, Brazil; ⁴ Department of Physical Activity Neuroscience, Salgado de Oliveira University, Niterói, Brazil; ⁵ Department of Neurology and Psychiatry, Sapienza University, Rome, Italy; ⁶ Unit of Neurology, S. Camillo-Forlanini Hospital, Rome, Italy

INTRODUCTION: Exergames represent a way to perform physical activity through active video games, serving as potentially useful tool in the field of neurorehabilitation. However, little is known regarding the possible role of exergames in improving cognitive functions in persons suffering from neurological disabilities.
EVIDENCE ACQUISITION: A search for relevant articles was carried out on PubMed/Medline, Scopus, PEDro, and Google Scholar. Only randomized controlled studies and non-randomized but controlled studies were retained. The following additional inclusion criteria were applied: studies focused on physical activity interventions carried out by means of exergames; populations targeted were affected by neurological disabilities; and reported results were related to cognitive outcomes. We calculated standardized mean differences (SMD) and pooled results using a random effects meta-analysis.
EVIDENCE SYNTHESIS: Of 520 abstracts screened, thirteen studies met the criteria to be included yielding a total of 465 participants, 233 randomized to exergames, and 232 allocated to the alternative or no intervention. The included studies varied in terms of studied populations (e.g., multiple sclerosis, post-stroke hemiparesis, Parkinson’s disease, dementia, dyslexia, Down syndrome), type and duration of interventions, and cognitive outcome measures. Exergames significantly improved executive functions (SMD=0.53, P=0.005; 8 studies, N.=380) and visuo-spatial perception (SMD=0.65, P<0.0001; 5 studies, N.=209) when compared to the alternative or no intervention. There were no significant differences for attention (SMD=0.57, P=0.07; 7 studies, N.=250) and global cognition (SMD=0.05, P=0.80; 6 studies, N.=161).
CONCLUSIONS: Exergames are a highly-flexible tool for rehabilitation of both cognitive and motor functions in adult populations suffering from various neurological disabilities and developmental neurological disorders. Additional high-quality clinical trials with larger samples and more specific cognitive outcomes are needed to corroborate these preliminary findings.
CLINICAL REHABILITATION IMPACT: Exergames could be considered either as a supplemental treatment to conventional rehabilitation, or as strategy to extend benefits of conventional programs at home.

KEY WORDS: Video games - Neurological disorders - Rehabilitation - Cognition