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Improved RNA base editing with guide RNAs mimicking highly edited endogenous ADAR substrates
Adenosine deaminase acting on RNA (ADAR)-mediated RNA base editing offers a safer alternative to genome editing for specific clinical applications...
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Enhancing rapid nitrogen freezer performance for Litchi fruit: a Taguchi-based approach to reduce cracking, time, and nitrogen consumption
This study employed the Taguchi technique to investigate the influence of various liquid nitrogen quick-freezing parameters on litchi fruit cracking,...
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MiR-218 Exhibits Anti-Leukemia Effects by Targeting CTNND2 in Primary Acute Erythroid Leukemia HEL Cells
Acute erythroid leukemia (AEL) is a rare acute myeloid leukemia (AML) subtype that is highly aggressive and is associated with a poor prognosis....
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Structural and dielectric performance study of microencapsulated graphene-reinforced silicone foam elastomer composites
Lightweight and flexible materials with high dielectric constant and low dielectric loss are highly desirable for capacitor energy storage...
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The Design Method of Cross-well Seismic Geometry Driven by Reverse Time Migration
Reasonable field acquisition geometry can not only guide seismic exploration to obtain sufficient geological information of target body, but also...
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Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65
Acute lung injury (ALI), which poses a significant public health threat, is commonly caused by sepsis. ALI is associated with permeability and...
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Stretchable optoelectronic synapses with ultraviolet to near-infrared perception for retina-inspired computing and vision-adaptive sensing
Stretchable optoelectronic synapses are attractive for intelligent perception, neuromorphic computation and visual adaptation. Here, we demonstrate a...
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Age-Specific Plasma Concentration, Efficacy and Safety of Ciprofol (Cipepofol) for Induction and Maintenance of General Anesthesia in Pediatric Patients Undergoing Elective Surgery: A Single-Arm Prospective, Pragmatic Trial
Background and ObjectiveCiprofol (Cipepofol) currently has well-established clinical research data in adult Chinese patients, but there is a lack of...
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FasterMLP efficient vision networks combining attention mechanisms and wavelet downsampling
The integration of Multi-layer Perceptrons (MLPs), Convolutional Neural Networks (CNNs), and attention mechanisms has been demonstrated to...
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Progression of the Residual Lesion in Cavernous Sinus Extra-Axial Cavernous Hemangioma After Surgery
Our study aimed to investigate the factors associated with residual cavernous sinus extra-axial cavernous hemangiomas (ECHs) progression after...
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MAO-B-triggered reaction for an optical triple-signal assay and AND logic gate application based on PEI-functionalized silver nanoparticles
A novel analytical method was designed and developed that exhibited ultraviolet–visible (UV–Vis), fluorescence (FL), and resonance Rayleigh...
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The physical properties of new MAX phase Zr3XC2(X=Cd, Sb): A DFT investigation
In this work, the effect of pressure on structural, mechanical, electronic and optical properties of Zr 3 XC 2 (X=Cd, Sb) predicted by first-principles...
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BDEL: A Backdoor Attack Defense Method Based on Ensemble Learning
Deep neural networks (DNNs) are susceptible to backdoor attacks. Previous researches have demonstrated the challenges in both removing poisoned...
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Applications and Future Prospects of Medical LLMs: A Survey Based on the M-KAT Conceptual Framework
The success of large language models (LLMs) in general areas have sparked a wave of research into their applications in the medical field. However,...
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A mammary gland secretion function exploratory study based on a quantitative comparison between milk and serum
Lactation is a complex physiological process, and the knowledge about the secretion of many milk components is limited. The objective of this study...
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Emergency neurosurgical hybrid operating platform for acute intracranial hemorrhage (E-HOPE)
BackgroundPrecise diagnosis and rapid treatment for acute complex intracranial hemorrhage (ICH) are crucial. The neurosurgical hybrid operating...
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Ablation mechanism and protection of aluminum alloy under high power laser irradiation: A review
Aluminum alloy is used as the support of final optical assembly because of its excellent mechanical properties, which constitutes the “skeleton” of...
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Ginger Essential Oil Extracted by Low-Temperature Continuous Phase Transition and Its Preservation Effect on Prepared Duck Meat
Ginger essential oil is widely used in the food industry due to its unique aroma and antibacterial activity. In this study, for the first time,...
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Expression and biological significance of topoisomerase II α (TOP2A) in oral squamous cell carcinoma
BackgroundTopoisomerase II α(TOP2A) is usually highly expressed in rapidly proliferating cells, and its expression is regulated by cell cycle. The...
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Cerebral hypoperfusion resulting from improper cannulation positioning during aortic dissection surgery: a case report
BackgroundSelective antegrade cerebral perfusion (sACP) is a crucial cerebral protection technique employed during aortic dissection surgeries...
