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E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development
Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death...
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Interaction of p53 with the Δ133p53α and Δ160p53α isoforms regulates p53 conformation and transcriptional activity
The TP53 gene encodes p53, a transcription factor involved in tumor suppression. However, TP53 also encodes other protein isoforms, some of which can...
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A Combined Pipe and Overland Flow Model to Support Urban Flood Risk Management: Case Study of the Espartes Watershed
Located in the Alpes-Maritimes (France), the Espartes watershed (1.6 km2) is characterized by a strong artificialization of both its surface and its...
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Environmental DNA from soil reveals the presence of a “lost” Afrotherian species
Environmental DNA (eDNA) sampling has attracted worldwide attention over the past few years as an emerging approach to characterising and monitoring...
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Enabling Floating-Point Arithmetic in the Coq Proof Assistant
Floating-point arithmetic is a well-known and extremely efficient way of performing approximate computations over the real numbers. Although it...
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3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice
Cellular senescence is a stable type of cell cycle arrest triggered by different stresses. As such, senescence drives age-related diseases and curbs...
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Adaptation to DNA Damage, an Asymptotic Approach for a Cooperative Non-local System
Following previous works about integro-differential equations of parabolic type modelling the Darwinian evolution of a population, we study a...
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Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
The p53 isoform, Δ133p53β, is critical in promoting cancer. Here we report that Δ133p53β activity is regulated through an aggregation-dependent...
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10 years of CEMARA database in the AnDDI-Rares network: a unique resource facilitating research and epidemiology in developmental disorders in France
BackgroundIn France, the Ministry of Health has implemented a comprehensive program for rare diseases (RD) that includes an epidemiological program...
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Automatic delineation and quantification of pulmonary vascular obstruction index in patients with pulmonary embolism using Perfusion SPECT-CT: a simulation study
BackgroundIn patients with pulmonary embolism (PE), there is a growing interest in quantifying the pulmonary vascular obtruction index (PVOI), which...
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Verifying Min-Plus Computations with Coq
Network-calculus is a theory that bounds delays in embedded networks such as AFDX networks used in modern airplanes. Effective computations rely on...
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Verifying the Mathematical Library of an UAV Autopilot with Frama-C
Ensuring safety of critical systems is crucial and is often attained by extensive testing of the system. Formal methods are now commonly accepted as...
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An unanticipated tumor-suppressive role of the SUMO pathway in the intestine unveiled by Ubc9 haploinsufficiency
Sumoylation is an essential posttranslational modification in eukaryotes that has emerged as an important pathway in oncogenic processes. Most human...
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Author Correction: AP-1 imprints a reversible transcriptional programme of senescent cells
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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68Ga-Labelled Carbon Nanoparticles for Ventilation PET/CT Imaging: Physical Properties Study and Comparison with Technegas®
PurposeThe use of 68 Ga-labelled carbon nanoparticles has been proposed for lung ventilation PET/CT imaging. However, no study has assessed the...
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Correlation of positron emission tomography ventilation-perfusion matching with CT densitometry in severe emphysema
BackgroundEmphysema severity is frequently measured on CT via densitometry. Correlation with scintigraphic and spirometric functional measures of...
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AP-1 imprints a reversible transcriptional programme of senescent cells
Senescent cells affect many physiological and pathophysiological processes. While select genetic and epigenetic elements for senescence induction...
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Pulmonary perfusion by iodine subtraction maps CT angiography in acute pulmonary embolism: comparison with pulmonary perfusion SPECT (PASEP trial)
ObjectiveTo assess the diagnostic accuracy of iodine map computed tomography pulmonary angiography (CTPA), for segment-based evaluation of lung...
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The Zachman Framework for Enterprise Architecture: An Explanatory IS Theory
Enterprise Architecture (EA) has had an interesting and often controversial history since its inception in the late 80’s by pioneers such as John...