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How growing up without siblings affects the adult brain and behaviour in the CHIMGEN cohort
With the worldwide increase in only-child families, it is crucial to understand the effects of growing up without siblings (GWS) on the adult brain,...
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Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes
The amygdala is a small but critical multi-nucleus structure for emotion, cognition and neuropsychiatric disorders. Although genetic associations...
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Major depressive disorder on a neuromorphic continuum
The heterogeneity of major depressive disorder (MDD) has hindered clinical translation and neuromarker identification. Biotyping facilitates solving...
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Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits
Socioeconomic status (SES) is a time-varying multidimensional construct with ill-defined dimension-specific and age-specific effects on brain and...
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Common neuroanatomical differential factors underlying heterogeneous gray matter volume variations in five common psychiatric disorders
Multifaceted evidence has shown that psychiatric disorders share common neurobiological mechanisms. However, the tremendous inter-individual...
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Using partially shared radiomics features to simultaneously identify isocitrate dehydrogenase mutation status and epilepsy in glioma patients from MRI images
Prediction of isocitrate dehydrogenase (IDH) mutation status and epilepsy occurrence are important to glioma patients. Although machine learning...
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Individualized gray matter morphological abnormalities unveil two neuroanatomical obsessive-compulsive disorder subtypes
Obsessive-compulsive disorder (OCD) is a highly heterogeneous disorder, with notable variations among cases in structural brain abnormalities. To...
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Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study
Recent studies have showed aberrant connectivity of cerebello-thalamo-cortical circuit (CTCC) in schizophrenia (SCZ), which might be a heritable...
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Nonacademic predictors of China medical licensing examination
BackgroundNational Medical Licensing Examination (NMLE) is the entrance exam for medical practice in China, and its general medical knowledge test...
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Optimizing hip MRI: enhancing image quality and elevating inter-observer consistency using deep learning-powered reconstruction
BackgroundConventional hip joint MRI scans necessitate lengthy scan durations, posing challenges for patient comfort and clinical efficiency....
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Structural-functional connectivity decoupling in multiscale brain networks in Parkinson’s disease
BackgroundParkinson’s disease (PD) is a progressive neurodegenerative disease associated with functional and structural alterations beyond the...
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Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer
Tryptophan (Trp) metabolism involves three primary pathways: the kynurenine (Kyn) pathway (KP), the 5-hydroxytryptamine (serotonin, 5-HT) pathway,...
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Dysfunction in sensorimotor and default mode networks in major depressive disorder with insights from global brain connectivity
Major depressive disorder (MDD) is recognized as a severe mental illness with imbalanced interactions among brain networks. However, the detailed...
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Altered cerebellar-cerebral dynamic functional connectivity in patients with pontine stroke: a resting-state fMRI study
Potential changes in patterns of dynamic functional network connections at the cerebellar-cerebral level in pontine infarction (PI) patients remain...
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Noninvasive prediction of BRAF V600E mutation status of pleomorphic xanthoastrocytomas with MRI morphologic features and diffusion-weighted imaging
ObjectivesSeeking a noninvasive predictor for BRAF V600E mutation status of pleomorphic xanthoastrocytomas (PXAs) is essential for their prognoses...
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Biologically interpretable multi-task deep learning pipeline predicts molecular alterations, grade, and prognosis in glioma patients
Deep learning models have been developed for various predictions in glioma; yet, they were constrained by manual segmentation, task-specific design,...
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Comprehensive analysis, diagnosis, prognosis, and cordycepin (CD) regulations for GSDME expressions in pan-cancers
The Gasdermin E gene ( GSDME ) plays roles in deafness and cancers. However, the roles and mechanisms in cancers are complex, and the same gene...
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Evaluation of preoperative magnetic resonance imaging features and diagnostic effectiveness of grades II and III intracranial solitary fibroma
ObjectivesTo explore the value of preoperative magnetic resonance imaging (MRI) characterization of intracranial solitary fibrous tumors (ISFT) and...
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Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm
Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we...
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Assessment of image quality and diagnostic accuracy for cervical spondylosis using T2w-STIR sequence with a deep learning-based reconstruction approach
ObjectivesTo investigate potential of enhancing image quality, maintaining interobserver consensus, and elevating disease diagnostic efficacy through...
