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Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans
Mechanotransduction channels are widely expressed in both vertebrates and invertebrates, mediating various physiological processes such as touch,...
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Altered gut microbiome and serum metabolome profiles associated with essential tremor
The genetic predisposition and environmental factors both trigger the complex neurological dyskinesia of essential tremor (ET). Gut dysbiosis may...
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Analysis of Common Genetic Variation of Anxiety Disorders in Essential Tremor
The objective of this study is to explore the association of common genetic variation of anxiety disorders and essential tremor (ET). We genotyped 25...
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Using partially shared radiomics features to simultaneously identify isocitrate dehydrogenase mutation status and epilepsy in glioma patients from MRI images
Prediction of isocitrate dehydrogenase (IDH) mutation status and epilepsy occurrence are important to glioma patients. Although machine learning...
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Research on magnetic resonance imaging in diagnosis of Alzheimer's disease
As a common disease in the elderly, the diagnosis of Alzheimer's disease (AD) is of great significance to the treatment and prognosis of the...
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High-performance presurgical differentiation of glioblastoma and metastasis by means of multiparametric neurite orientation dispersion and density imaging (NODDI) radiomics
ObjectivesTo evaluate the performance of multiparametric neurite orientation dispersion and density imaging (NODDI) radiomics in distinguishing...
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Early-onset familial essential tremor is associated with nucleotide expansions of spinocerebellar ataxia in China
BackgroundEssential tremor (ET) is a neurological disease characterized by action tremor in upper arms. Although its high heritability and prevalence...
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Coformer: Collaborative Transformer for Medical Image Segmentation
Transformer has shown significant power for medical image analysis. However, the inherent design of the Transformer limits the ability to extract...
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Radiomic texture analysis based on neurite orientation dispersion and density imaging to differentiate glioblastoma from solitary brain metastasis
BackgroundWe created discriminative models of different regions of interest (ROIs) using radiomic texture features of neurite orientation dispersion...
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Fuzzy Quantitative Management Principles, Methodologies and Applications
This book is devoted to fuzzy quantitative studies in managerial science, discussing the philosophical background and decision-making essentials. For...
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Ligand activation mechanisms of human KCNQ2 channel
The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-current, which helps to stabilize the membrane potential. KCNQ2 can be...
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Integrated analyses of metabolomics and transcriptomics reveal the potential regulatory roles of long non-coding RNAs in gingerol biosynthesis
BackgroundAs the characteristic functional component in ginger, gingerols possess several health-promoting properties. Long non-coding RNAs (lncRNAs)...
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The clinical characteristics of neuronal intranuclear inclusion disease and its relation with inflammation
BackgroundNeuronal intranuclear inclusion disease (NIID) is a great imitator with a broad spectrum of clinical manifestations that include dementia,...
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Prevalence and factors associated with knee osteoarthritis among middle-aged and elderly individuals in rural Tianjin: a population-based cross-sectional study
BackgroundThe prevalence of osteoarthritis has been investigated in many countries and regions. Considering the wide differences in ethnicity,...
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Association Analysis of 27 Single Nucleotide Polymorphisms in a Chinese Population with Essential Tremor
Genetic factors play a major role in essential tremor (ET) pathogenesis. This study aimed to assess variant burden in ET-associated genes in a...
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Research on the Real-Time Dynamic Evaluation of Public Transport Passenger Service Satisfaction Based on the Internet
The current method of evaluating passenger satisfaction primarily adopts the traditional static evaluation mode, which can hardly satisfy the dynamic...
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Brain microstructural changes in essential tremor patients and correlations with clinical characteristics: a diffusion kurtosis imaging study
ObjectiveEssential tremor (ET) is the second most common movement disorder; however, the pathophysiological mechanism of ET is unclear. We aimed to...
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Perspectives in Combining Fuzzy and AI Techniques in Quantitative Management
As the progress of science and technology, we are entering to the Internet digital era. The new generation of project management will be implemented...
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The Conceptual Investigation of “Deep Data” and “Deep Knowledge”
The conventional data base (DB) and knowledge base (KB) attached to conventional decision supporting system (DSS) will not be sufficient to the needs...