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Add hover help over results, highlight out-of-range calculations #103

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ChrisMoth opened this issue Mar 24, 2025 · 0 comments
Open

Add hover help over results, highlight out-of-range calculations #103

ChrisMoth opened this issue Mar 24, 2025 · 0 comments

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@ChrisMoth
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On the Report page, the sections are difficult to interpret for novices (and difficult for me to recall from week to week). It would help to add a block of text like this for each tool.

Calculation results which are "out of range" should be color highlighted.

Some starting points for discussion:

PathProx gives.... (note ROC curve importance)

ScanNet gives (per-residue) likelihood of being P-P-I site

Values >0.5 are considered positive. Please see https://pubmed.ncbi.nlm.nih.gov/36116806/

MuSiteDeep (per-residue) PTM gives Gene,Native Residue,PTM Residue,Type,Probability (best results for: pTyr,NGly,N-Ace,M-Arg,M-Lys,Palm-Cys,H-Lys,Sumoyl; Lower PR-AUC: P-Ser/Thr,O-gly,Ubiq,H-Pro) Please see https://pubmed.ncbi.nlm.nih.gov/32324217/

DiGePred predicts digenic interactions with lower false positive rate than DIEP, and displays the evidence in the mouse-over.

Values > .50 are positive. Please see https://pubmed.ncbi.nlm.nih.gov/34529933/

DIEP has higher sensitivity than DiGePred (89% v 42%) with higher FP rate.

Please see https://pubmed.ncbi.nlm.nih.gov/35891796/

Rate4Site (from ConSurf) gives zscores; lower score is more conserved than avg.

Please see https://pubmed.ncbi.nlm.nih.gov/12169533/

COSMIS gives zscores; lower score (red) less tolerant to missense mutations

pathogenics have median -1.1, high-conf (p-value<0.01) below -2.33

Please see https://pubmed.ncbi.nlm.nih.gov/35672414/

Add shading to any scores that are above the threshold for that tool.

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