Abstract
In this paper, a non-invasive blood glucose sensing system is presented using near infra-red(NIR) spectroscopy. The signal from the NIR optodes is processed using artificial neural networks (ANN) to estimate the glucose level in blood. In order to obtain accurate values of the synaptic weights of the ANN, inverse delayed (ID) function model of neuron has been used. The ANN model has been implemented on field programmable gate array (FPGA). Error in estimating glucose levels using ANN based on ID function model of neuron implemented on FPGA, came out to be 1.02 mg/dl using 15 hidden neurons in the hidden layer as against 5.48 mg/dl using ANN based on conventional neuron model.





















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References
Heise, H. M., In: Meyers, R. A. (Ed.), Encyclopedia of analytical chemistry, vol. 1. Wiley, New York, pp. 1–27, 2000.
DCCT Group, Intensive diabetes treatment and cardiovascular disease in patients with type1 diabetes. N. Eng. J. Med. 353(25):2643–2653, 2005.
Zhang, P., Zhang, X., Brown, J., Vistisen, D., Sicree, R., Shaw, J., and Nichols, G., Global healthcare expenditure on diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 87:293–301, 2010.
Whiting, D. R., Guariguata, L., Weil, C., and Shaw, J., IDF diabetes atlas: Global estimates of the prevelance of diabetes for 2011 and 2030. Diabetes Res. Clin. Pract. 94:311–321, 2011.
Guariguata, L., Whiting, D. R., Weil, C., and Unwin, N., The international diabetes federation diabetes atlas methodology for estimating global and national prevalence of diabetes in adults. Diabetes Res. Clin. Pract. 94:322–332, 2011.
Skyler, J. S., Continuous glucose monitoring: An overview of its development, Diabetes Technol. Ther. 11(sup. 1), 2009.
Rabiee, A., Andreasik, V., Abu-Hamdah, R., Galiatsatos, P., Khouri, Z., Robert, B., Gibson, M. D., Andersen, D. K., and Dariush, E., Numerical and clinical accuracy of a continuous glucose monitoring system during intravenous insulin therapy in the surgical and burn intensive care units. J. Diabetes Sci. Technol. 3(4):951–959, 2009.
Tani, S., Marukami, T., Matsuda, A., Shindo, A., Takemoto, K., and Inada, H., Development of a health management support system for patients with diabetes mellitus at home. J. Med. Syst. 34(3):223–228, 2010.
Baig, M. M., and Gholamhosseini, H., Smart health monitoring systems: an overview of design and modeling. J. Med. Syst. 37(2):9898, 2013.
Jameson, R., Lorence, D., and Lin, J., Data capture of transdermal glucose monitoring through computerized appliance-based virtual remote sensing and alert systems. J. Med. Syst. 36(4):2193–2201, 2012.
Acharya, U. R., Tong, J., Subbhuraam, V. S., Chua, C. K., Ha, T. P., Ghista, D. N., Chattopadhyay, S., Ng, K. H., and Suri, J. S., Computer-based identification of type 2 diabetic subjects with and without neuropathy using dynamic planter pressure and principal component analysis. J. Med. Syst. 36(4):2483–2491, 2012.
Malin,S. F., Ruchiti, T. L., Blank, T. B., Thennadil, S. U., Monfre, S. L., Noninvasive prediction of glucose by near-infrared diffuse reflectance spectroscopy. Clin. Chem. 45:651–658, 999.
Jeon, K. J., Hwang, I. D., Hahn, S., Yoon, G., Comparison between transmittance and reflectance measurements in glucose determination using near infrared spectroscopy. J. Biomed. Opt. (11):014022, 2006.
Amerov, A. K., Chen, J., Small, G. W., and Arnold, M. A., Scattering and absorption effects in the determination of glucose in whole blood by near-infrared spectroscopy. Anal. Chem. 77(14):4587–4594, 2005.
PerezGandia, C., Facchinetti, A., Sparacino, G., Cobelli, C., Gomez, E. J., Rigla, M., de Leiva, A., and Hernando, M. E., Artificial neural network algorithm for on-line glucose prediction from continuous glucose monitoring. Diabetes Technol.Ther. 12:81–88, 2010.
Robertson G, Lehman D, Sandham, Hamilton, Blood glucose prediction using artificial neural networks trained with the AIDA diabetes simulator: A proof-of-concept pilot study. J. Electr. Comput. Eng. Article ID 681786:11, 2011.
Gogou, G., Maglaveras, N., Ambrosiadou, B. V., Goulis, D., and Pappas, C., A neural network approach in diabetes management by insulin administration. J. Med. Syst. 25(2):119–131, 2001.
Nakajima, K., Hayakawa, Y., Characteristics of inverse delayed model for neural computation, Proceedings of international symposium on nonlinear Theory and its Applications (202) 861–864.
FitzHugh, R., Impulses and physiological states in theoretical models of nerve membrane. Biophys. J. 1(6):445–466, 1961.
Hayakawa, Y., Denda, T., and Nakajima, K., Inverse function delayed model for optimization problems. Proc. KES 1:981–987, 2004.
Amerov, A. K., Chen, J. and Arnold, M. A., Molar absorptivities of glucose and other biological molecules in aqueous solutions over the first overtone and combination regions of the near-infraredspectrum. Appl. Spectrosc.
Pavlyuchko, I., Vasilyev, E. V., Gribovb, L. A., Calculations of molecular ir spectra in the overtone and combination frequency regions
Yamakoshi, Y., Ogawa, M., Yamakoshi, T., Tamura, T., and Yamakoshi, K., Multivariate regression and discreminant calibration models for a novel optical non-invasive blood glucose measurement method named pulse glucometry. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2009:126–129, 2009. doi:10.1109/IEMBS.2009.5335104.
Yamakoshi, Y., Pulse glucometry: A new approach for non-invasive blood glucose measurement using instantaneous differential near infrared spectrophotometry.
Yanai, H., and Sawada, Y., Associative memory network composed of neurons with hysteresis property. Neural Netw. 3:223–228, 1990.
Phee, H. K, Tung,W. L, Quek, C, A personalized approach to insulin regulation using brain-inspired neural semantic memory in diabetic glucose control. IEEE congress On Evolutionary Computation Singapore, pp.2644–2651, 2007.
Nordstrom, T. Svensson, B., Using and designing massively parallel computers for artificial neural networks. J. Parallel Distrib. Process. (3): 260–285, 1998.
Zhang, M., Vassiliadis, S., and Delgado-Frias, J. G., Sigmoid generators for neural computing using piecewise approximations. IEEE Trans. Comput. 45(9):1045–1049, 1996. ISSN: 0018–9340.
Guccione, S. A., and Gonzalez, M. J., A neural network implementation using reconfigurable architectures. Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, 2006.
Kukar, M., Transductive reliability estimation in medical diagnosis. Artif. Intell. Med. 29:81–106, 2003.
Vashist, S. K., Continuous glucose monitoring systems: A review. Diagnostics 3:385–392, 2013.
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Ramasahayam, S., Koppuravuri, S.H., Arora, L. et al. Noninvasive Blood Glucose Sensing Using Near Infra-Red Spectroscopy and Artificial Neural Networks Based on Inverse Delayed Function Model of Neuron. J Med Syst 39, 166 (2015). https://doi.org/10.1007/s10916-014-0166-2
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DOI: https://doi.org/10.1007/s10916-014-0166-2