Abstract
An approximation method for faster generation of explanations in medical imaging classifications is presented. Previous results in literature show that generating detailed explanations with LIME, especially when fine tuning parameters, is very computationally and time demanding. This is true both for manual and automatic parameter tuning. The alternative here presented can decrease computation times by several orders of magnitude, while still identifying the most relevant regions in images. The approximated explanations are compared to previous results in literature and medical expert segmentations for a dataset of histopathology images used in a binary classification task. The classifications of a convolutional neural network trained on this dataset are explained by means of heatmap visualizations. The results show that it seems to be possible to achieve much faster computation times by trading off finer detail in the explanations. This could give more options for users of artificial intelligence black box systems in the context of medical imaging tasks, in regards to generating insight or auditing decision systems.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Adadi, A., Berrada, M.: Peeking inside the black-box: a survey on explainable artificial intelligence (XAI). IEEE Access 6, 52138–52160 (2018)
Huang, Y., Chung, A.C.S.: Evidence localization for pathology images using weakly supervised learning. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11764, pp. 613–621. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32239-7_68
Kaggle: Histopathologic cancer detection. https://www.kaggle.com/c/histopathologic-cancer-detection
Miotto, R., Wang, F., Wang, S., Jiang, X., Dudley, J.T.: Deep learning for healthcare: review, opportunities and challenges. Brief. Bioinform. 19, 1236–1246 (2017)
Pocevičiūtė, M., Eilertsen, G., Lundström, C.: Survey of XAI in digital pathology. In: Holzinger, A., Goebel, R., Mengel, M., Müller, H. (eds.) Artificial Intelligence and Machine Learning for Digital Pathology. LNCS (LNAI), vol. 12090, pp. 56–88. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-50402-1_4
Ribeiro, M.T., Singh, S., Guestrin, C.: Why should i trust you?: explaining the predictions of any classifier. In: Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, pp. 1135–1144 (2016)
Samek, W., Montavon, G., Vedaldi, A., Hansen, L.K., Müller, K.-R. (eds.): Explainable AI: Interpreting, Explaining and Visualizing Deep Learning. LNCS (LNAI), vol. 11700. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-28954-6
Palatnik de Sousa, I., Maria Bernardes Rebuzzi Vellasco, E.: Local interpretable model-agnostic explanations for classification of lymph node metastases. Sensors 19(13), 2969 (2019)
Palatnik de Sousa, I., Maria Bernardes Rebuzzi Vellasco, M., Costa da Silva, E.: Evolved explainable classifications for lymph node metastases. arXiv preprint arXiv:2005.07229 (2020)
Tang, Z., et al.: Interpretable classification of Alzheimer’s disease pathologies with a convolutional neural network pipeline. Nat. Commun. 10(1), 1–14 (2019)
Veeling, B.S., Linmans, J., Winkens, J., Cohen, T., Welling, M.: Rotation equivariant CNNs for digital pathology. In: Frangi, A.F., Schnabel, J.A., Davatzikos, C., Alberola-López, C., Fichtinger, G. (eds.) MICCAI 2018. LNCS, vol. 11071, pp. 210–218. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00934-2_24
Acknowledgment
This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal do Nível Superior - Brasil (CAPES), Finance Code 001. The authors also acknowledge the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Rio de Janeiro (FAPERJ) for the funding to this research.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
de Sousa, I.P., Vellasco, M.M.B.R., da Silva, E.C. (2020). Approximate Explanations for Classification of Histopathology Patches. In: Koprinska, I., et al. ECML PKDD 2020 Workshops. ECML PKDD 2020. Communications in Computer and Information Science, vol 1323. Springer, Cham. https://doi.org/10.1007/978-3-030-65965-3_35
Download citation
DOI: https://doi.org/10.1007/978-3-030-65965-3_35
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-65964-6
Online ISBN: 978-3-030-65965-3
eBook Packages: Computer ScienceComputer Science (R0)