Abstract
In this paper we proposed a Protein Ontology to integrate protein data and information from various Protein Data Sources. Protein Ontology provides the technical and scientific infrastructure and knowledge to allow description and analysis of relationships between various proteins. Protein Ontology uses relevant protein data sources of information like PDB, SCOP, and OMIM. Protein Ontology describes: Protein Sequence and Structure Information, Protein Folding Process, Cellular Functions of Proteins, Molecular Bindings internal and external to Proteins, and Constraints affecting the Final Protein Conformation. We also created a database of 10 Major Prion Proteins available in various Protein data sources, based on the vocabulary provided by Protein Ontology. Details about Protein Ontology are available online at http://www.proteinontology.info/.
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Weissiga, H., Bourne, P.E.: Protein structure resources. Biological Crystallography 58, 908–915 (2002)
Westbrook, J., Feng, Z., et al.: The Protein Data Bank: unifying the archive. Nucleic Acid Research 30(1), 245–248 (2002)
Bhat, T.N., Bourne, P.E., et al.: The PDB data uniformity project. Nucleic Acid Research 29(1), 214–218 (2001)
Bernstein, F.C., Koetzle, T.F., et al.: The Protein Data Bank: a computer-based archival file for macromolecular structures. Journal of Molecular Biology 112(3), 535–542 (1977)
Conte, L.L., Ailey, B., et al.: SCOP: a Structural Classification of Proteins database. Nucleic Acids Research 28(1), 257–259 (2000)
Murzin, A.G., Brenner, S.E., et al.: SCOP: A Structural Classification of Proteins Database for the Investigation of Sequences and Structures. Journal of Molecular Biology 247, 536–540 (1995)
Mckusick, V. A.: Online Mendelian Inheritance in Man, OMIM. Baltimore, MD, Johns Hopkins University, National Center for Biotechnology Information, and National Library of Medicine (2000)
Schulze-Kremer, S.: Ontologies for Molecular Biology. In: Proceedings of Third Pacific Symposium on Biocomputing, Hawaii, AAAI Press, pp. 693–704. AAAI Press, Hawaii (1998)
Karp, P., Riley, M., et al.: Ecocyc: Electronic Encyclopedia of E.coli genes and metabolism. Nucleic Acids Research 26, 50 (1998)
Borgida, A.: Description Logics in Data Management. IEEE Transactions on Knowledge and Data Engineering 7, 671–682 (1995)
GO. Creating the Gene Ontology Resource: Design and Implementation. Genome Research 11, 1425–1433 (2001)
G.: Gene Ontology: looking backwards and forwards. Genome Biology 6(1)Â 103, 103.1-103.4 (2004)
Altmann, R.B., Bada, M., et al.: riboweb: An Ontology-Based System for Collaborative Molecular Biology. IEEE Intelligent Systems 76, 68–76 (1999)
Westbrook, J., Ito, N., et al.: PDBML: The Representation of Archival Macromolecular Structure Data in XML. Bioinformatics 21(7), 988–992 (2005)
Mani, I., Hu, Z., et al.: PRONTO: A Large-scale Machine-induced Protein Ontology. In: 2nd Standards and Ontologies for Functional Genomics Conference, UK (SOFG 2004)
Sidhu, A.S., Dillon, T.S., et al.: An Ontology for Protein Data Models. In: 27th annual international conference of the ieee engineering in medicine and biology society 2005 (IEEE EMBC 2005), Shanghai, China, IEEE Press, Los Alamitos (2005)
Sidhu, A.S., Dillon, T.S., et al.: Ontology-based Knowledge Representation of Protein Data. In: 3rd International IEEE Conference on Industrial Informatics, Perth, Australia, IEEE CS Press, Los Alamitos (2005)
Sidhu, A.S., Dillon, T.S., et al.: Protein Ontology: Vocabulary for Protein Data. In: 3rd IEEE International Conference on Information Technology and Applications, Sydney, Australia, IEEE CS Press, Los Alamitos (2005)
Sidhu, A.S., Dillon, T.S., et al.: A Unified Representation of Protein Structure Databases (Book Section). In: Reddy, M.S., Khanna, S. (eds.) Biotechnological Approaches for Sustainable Development, Mumbai, India, pp. 396–408. Allied Publishers Pvt. Ltd (2004)
Sidhu, A.S., Dillon, T.S., et al.: An XML based semantic protein map. In: Zanasi, A., Ebecken, N.F.F., Brebbia, C.A. (eds.) Data Mining 2004, Malaga, Spain, vol. 10, pp. 51–60. WIT Press, Southampton (2004)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Sidhu, A.S., Dillon, T.S., Chang, E. (2005). Ontological Foundation for Protein Data Models. In: Meersman, R., Tari, Z., Herrero, P. (eds) On the Move to Meaningful Internet Systems 2005: OTM 2005 Workshops. OTM 2005. Lecture Notes in Computer Science, vol 3762. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11575863_113
Download citation
DOI: https://doi.org/10.1007/11575863_113
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-29739-0
Online ISBN: 978-3-540-32132-3
eBook Packages: Computer ScienceComputer Science (R0)